7. 관련 질환
류마티스
8. 역사
9. 기타
● 역할
NF-kB-targeted therapeutics in
inflammatory diseases.
NF-kB signaling plays a pathogenic role in various
inflammatory diseases;
therefore, there are many therapeutic strategies
for inflammatory diseases
aimed at blocking NF-kB activity.
First, inhibition of IKK kinase activity.
Drugs such as aspirin and salicylate
have the ability to specifically
inhibit IKK, thereby preventing
phosphorylation of IkBa.
Second, inhibition of protease activity.
Drugs such as PS-341 and lactacystin
specifically inhibit 26S proteasome complex,
thereby preventing IkBa degradation.
Third, inhibition of nuclear translocation.
Drugs such as tacrolimus and IkBa super-repressor
specifically prevent NF-kB subunits Rela,
p50, c-Rel and other members from
entering the nucleus.
Finally, inhibition of DNA binding.
Drugs such as glucocorticoids and PPAR agonists
have the ability to prevent NF-kB subunits from
binging with target genes, and therefore
inhibit the transcription.
https://www.nature.com/articles/sigtrans201723
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